Article
[Preimplantation genetic diagnosis for beta-thalassemia].
Zhonghua yi xue za zhi - 25 Feb 2003
Jiao Ze-xu, Zhuang Guan-lun, Zhou Can-quan, Shu Yi-min, Liang Xiao-yan, Li Jie, Zhang Min-fang, Deng Ming-fen
Abstract excerpt
OBJECTIVE: To investigate the effect of in vitro fertilization and embryo transfer (IVF-ET) and preimplantation genetic diagnosis (PGD) for the couples at risk of having children with beta-thalassemia. METHODS: Four couples carrying different thalassemia mutations received standard IVF treatment. Embryo biopsy was conducted. Single blastomeres were genotyped by a protocol involving primer extension...
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