Article
Puberty and genetic susceptibility to breast cancer in a case-control study in twins.
The New England journal of medicine - 5 Jun 2003
Hamilton Ann S, Mack Thomas M
Abstract excerpt
BACKGROUND: Breast cancer is thought to result from excessive cumulative exposure to ovarian hormones. Different predictors of hereditary and sporadic breast cancer suggest different pathogenic mechanisms. Affected twin pairs may help to illustrate such differences. METHODS: We obtained information from 1811 pairs of female twins, one or both of whom had breast cancer. The pairs were stratified according to...
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