Article
Association of I27L polymorphism of hepatocyte nuclear factor-1 alpha gene with high-density lipoprotein cholesterol level.
The Journal of clinical endocrinology and metabolism - 1 Jun 2003
Babaya Naru, Ikegami Hiroshi, Fujisawa Tomomi, Nojima Koji, Itoi-Babaya Michiko, Inoue Kaori, Nakura Jun, Abe Michiko, Yamamoto Miyuki, Jin Jin Ji, Wu Zhihong, Miki Tetsuro, Fukuda Masakatsu, Ogihara Toshio
Abstract excerpt
The serum level of high-density lipoprotein cholesterol (HDL-c), which protects against the development of atherosclerosis, is under genetic control. However, the genetic components responsible for the serum HDL-c level are yet to be determined. A recent knockout mouse study demonstrated that hepatocyte nuclear factor-1 alpha (HNF-1 alpha) is an essential transcriptional regulator of HDL-c metabolism. In this...
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