Article
Activated protein C resistance acquired through liver transplantation and associated with recurrent venous thrombosis.
Journal of hepatology - 1 Jun 2003
Leroy-Matheron Catherine, Duvoux Christophe, Van Nhieu Jeanne Tran, Leroy Karen, Cherqui Daniel, Gouault-Heilmann Michèle
Abstract excerpt
We report a new case of recurrent, extra-hepatic, deep vein thrombosis occurring after orthotopic liver transplantation for hepatocellular carcinoma complicating 'mixed' alcoholic and post-hepatitic C cirrhosis. Coagulation tests showed activated protein C resistance. The patient's genomic DNA was negative for the factor V Leiden mutation. Analysis of the grafted liver DNA showed that the donor was a heterozygous...
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