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Article

Reducing maintenance metabolism by metabolic engineering of respiration improves riboflavin production by Bacillus subtilis.

Metabolic engineering - 1 Jan 2003

Zamboni Nicola, Mouncey Nigel, Hohmann Hans-Peter, Sauer Uwe

Abstract excerpt

We present redirection of electron flow to more efficient proton pumping branches within respiratory chains as a generally applicable metabolic engineering strategy, which tailors microbial metabolism to the specific requirements of high cell density processes by improving product and biomass yields. For the example of riboflavin production by Bacillus subtilis, we reduced the rate of maintenance metabolism by...

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PMID: 12749844
DOI: 10.1016/s1096-7176(03)00007-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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