Article
Crystal structure of the intrinsically flexible addiction antidote MazE.
The Journal of biological chemistry - 25 Jul 2003
Loris Remy, Marianovsky Irina, Lah Jurij, Laeremans Toon, Engelberg-Kulka Hanna, Glaser Gad, Muyldermans Serge, Wyns Lode
Abstract excerpt
A specific camel VHH (variable domain of dromedary heavy chain antibody) fragment was used to crystallize the intrinsically flexible addiction antidote MazE. Only 45% of the polypeptide chain is found ordered in the crystal. The MazE monomer consisting of two beta-hairpins connected by a short alpha-helix has no hydrophobic core on its own and represents only one half of a typical protein domain. A complete...
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