Article
The deletion polymorphism in the angiotensin-converting enzyme gene is a moderate risk factor for venous thromboembolism.
Thrombosis and haemostasis - 1 May 2003
von Depka Mario, Czwalinna Andreas, Wermes Cornelia, Eisert Roswith, Scharrer Inge, Ganser Arnold, Ehrenforth Silke
Abstract excerpt
ACE displays potent vasoconstrictive effects, attenuation of fibrinolysis, and platelet activation and aggregation, thus possibly promoting venous thromboembolism (VTE). The ACE gene contains an insertion (I) or deletion (D) polymorphism accounting for 50% of the variation in serum ACE concentration. To evaluate the role of the I/D polymorphism in VTE, its prevalence was determined in 931 patients with VTE and...
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