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Article

Frequency of microsatellite instability in unselected sebaceous gland neoplasias and hyperplasias.

The Journal of investigative dermatology - 1 May 2003

Kruse Roland, Rütten Arno, Schweiger Nadine, Jakob Eva, Mathiak Micaela, Propping Peter, Mangold Elisabeth, Bisceglia Michele, Ruzicka Thomas

Abstract excerpt

Sebaceous gland neoplasias are the cutaneous manifestation of the Muir-Torre syndrome, which is known to be a phenotypical variant of hereditary nonpolyposis colorectal cancer. Both hereditary nonpolyposis colorectal cancer and Muir-Torre syndrome are caused by inherited DNA mismatch repair defects. As a prominent molecular genetic feature, all tumors associated with a DNA mismatch repair defect exhibit high...

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Identifiers

PMID: 12713593
DOI: 10.1046/j.1523-1747.2003.12125.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Frequency of microsatellite instability in unselected sebaceous gland neoplasias and hyperplasias.PMID 12713593Read ↗

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Microsatellite instability in Muir-Torre syndrome.Semantic proximity Read ↗

Microsatellite instability and its relevance to cutaneous tumorigenesis.Semantic proximity Read ↗

Somatic MMR gene mutations as a cause for MSI-H sebaceous neoplasms in Muir-Torre syndrome-like patients.Semantic proximity Read ↗

Cutaneous sebaceous neoplasms as markers of Muir‐Torre syndrome: a diagnostic algorithmSemantic proximity Read ↗

Mismatch Repair Proteins Expression and Microsatellite Instability in Skin Lesions With Sebaceous Differentiation: A Study in Different Clinical Subgroups With and Without Extracutaneous CancerSemantic proximity Read ↗

Identification of Muir-Torre syndrome among patients with sebaceous tumors and keratoacanthomas: role of clinical features, microsatellite instability, and immunohistochemistry.Semantic proximity Read ↗

Clinical and Molecular Features of Skin Malignancies in Muir-Torre Syndrome.Semantic proximity Read ↗

Muir-Torre phenotype has a frequency of DNA mismatch-repair-gene mutations similar to that in hereditary nonpolyposis colorectal cancer families defined by the Amsterdam criteria.Semantic proximity Read ↗

The DNA mismatch repair system in sebaceous tumors: an update on the genetics and workup of Muir-Torre syndrome.Semantic proximity Read ↗

Cystic Sebaceous Tumors as Marker Lesions for the Muir-Torre SyndromeSemantic proximity Read ↗

"Second hit" in sebaceous tumors from Muir-Torre patients with germline mutations in MSH2: allele loss is not the preferred mode of inactivation.Semantic proximity Read ↗

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