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Article

Mutations in the Wolfram syndrome type 1 gene (WFS1) define a clinical entity of dominant low-frequency sensorineural hearing loss.

Archives of otolaryngology--head & neck surgery - 1 Apr 2003

Lesperance Marci M, Hall James W, San Agustin Theresa B, Leal Suzanne M

Abstract excerpt

OBJECTIVE: To describe low-frequency sensorineural hearing loss (LFSNHL) inherited as a dominant trait in 3 families and in 1 sporadic case. DESIGN: Longitudinal clinical study from 1968 to 2001. SETTING: Tertiary care hospital; field studies conducted by molecular genetic research laboratory. PARTICIPANTS: Dominant LFSNHL families. INTERVENTIONS: Questionnaires, serial audiograms, and interviews, correlated with...

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Source

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Identifiers

PMID: 12707187
DOI: 10.1001/archotol.129.4.411
PMCID: PMC6145174

Genes

WFS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in the Wolfram syndrome type 1 gene (WFS1) define a clinical entity of dominant low-frequency sensorineural hearing loss.PMID 12707187Read ↗

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