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Article

Expression of short-chain acyl-CoA dehydrogenase (SCAD) proteins in the liver of SCAD deficient mice after hydrodynamic gene transfer.

Molecular genetics and metabolism - 1 Apr 2003

Holm David A, Dagnaes-Hansen Frederik, Simonsen Henrik, Gregersen Niels, Bolund Lars, Jensen Thomas G, Corydon Thomas J

Abstract excerpt

Hydrodynamic administration of naked DNA was investigated as a method for in vivo expression of variant proteins involved in metabolic diseases, using short-chain acyl-CoA dehydrogenase (SCAD) deficient mice (BALB/cByJ) as a model. Human SCAD wild-type (WT) and two disease-associated SCAD variant proteins (R147W and G185S) were expressed in mouse liver by means of single injections of SCAD cDNA under the control...

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PMID: 12706376
DOI: 10.1016/s1096-7192(03)00038-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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