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Article

A Novel Methionine-Based Signaling Mechanism Regulating the Expression of Thymidylate Synthase

20 Jul 2003

Abstract excerpt

Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear zinc finger DNA-binding protein that is implicated in the repair of DNA damage. Inhibition of PARP-1 through genetic knockouts causes cells to become hypersensitive to various chemotherapeutic agents. We tested the chemopotentiating ability of the PARP-1 inhibitor, CEP-6800, when used in combination with temozolomide (TMZ), irinotecan (camptothecin or SN38), and...

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Identifiers

PMID: 12700281
DOI: 10.4161/cbt.2.4.460

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