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Article

Replication restart in gyrB Escherichia coli mutants.

Molecular microbiology - 1 May 2003

Grompone Gianfranco, Ehrlich S Dusko, Michel Bénédicte

Abstract excerpt

Gyrase is an essential topoisomerase in bacteria that introduces negative supercoils in DNA and relaxes the positive supercoils that form downstream of proteins tracking on DNA, such as DNA or RNA polymerases. Two gyrase mutants that suffer partial loss of function were used here to study the need for replication restart in conditions in which gyrase activity is affected. We show that the preprimosomal protein...

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PMID: 12694626
DOI: 10.1046/j.1365-2958.2003.03480.x

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