Article
Angiotensin-converting enzyme and endothelial nitric oxide synthase polymorphisms in patients with atrial fibrillation.
Pacing and clinical electrophysiology : PACE - 1 Jan 2003
Gensini Francesca, Padeletti Luigi, Fatini Cinzia, Sticchi Elena, Gensini Gian Franco, Michelucci Antonio
Abstract excerpt
Experimental studies have shown a significant increase in angiotensin-converting enzyme (ACE) expression in atrial tissue of AF patients. ACE regulates the synthesis of endothelial nitric oxide (NO), which modulates autonomic nervous activity involved in the development of AF. The aim of the study was to evaluate the prevalence of ACE insertion/deletion and endothelial NO synthase (eNOS) T-786C, G894T, and 4a/4b...
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