Article
Polymorphic mutations of the Mn-SOD gene in intact human lymphocytes and oral squamous cell carcinoma cell lines.
Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Feb 2003
Kamatani Takaaki, Yamamoto Tetsuya, Yoneda Kazunori, Osaki Tokio
Abstract excerpt
Mutations of the superoxide dismutase (SOD) genes are associated with neoplastic and non-neoplastic diseases. However, the existence of polymorphic mutations of manganese SOD (Mn-SOD) has not been explored in squamous cell carcinoma (SCC) cells or in normal cells. In the present study, we examined mutations in the 5' flanking region of the Mn-SOD gene and Mn-SOD mRNA using 10 human oral SCC (OSC) cell lines and...
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