Article
Expression profiling reveals altered satellite cell numbers and glycolytic enzyme transcription in nemaline myopathy muscle.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2003
Sanoudou Despina, Haslett Judith N, Kho Alvin T, Guo Shaoqiang, Gazda Hanna T, Greenberg Steven A, Lidov Hart G W, Kohane Isaac S, Kunkel Louis M, Beggs Alan H
Abstract excerpt
The nemaline myopathies (NMs) are a clinically and genetically heterogeneous group of disorders characterized by nemaline rods and skeletal muscle weakness. Mutations in five sarcomeric thin filament genes have been identified. However, the molecular consequences of these mutations are unknown. Using Affymetrix oligonucleotide microarrays, we have analyzed the expression patterns of >21,000 genes and expressed...
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