Article
LPO and ethanol biotransformation systems in the liver as markers of predisposition to ethanol hepatotoxicity.
Bulletin of experimental biology and medicine - 1 Dec 2002
Bushma M I, Ambrushkevich Yu G, Zimatkin S M, Bushma K M, Omel'yanchik S N, Slyshenkov V S, Mel'nichenko N G, Kuz'mich A B, El'chaninova M A
Abstract excerpt
An original experimental model for detecting organ-specific markers of predisposition to ethanol hepatotoxicity is proposed. A relationship between congenital activity of LPO processes in rat liver (before ethanol intoxication) and the type and severity of ethanol-induced damage to the liver was demonstrated using methods of mathematical modeling. It was proven that intact rats with genetically high MDA levels in...
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