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Article

Double minutes containing amplified <i>bcr‐abl</i> fusion gene in a case of chronic myeloid leukemia treated by imatinib

26 Mar 2003

Abstract excerpt

Amplification of the bcr-abl fusion gene has recently been associated with resistance to imatinib therapy in chronic myeloid leukemia (CML). A 55-yr-old man was diagnosed with Philadelphia (Ph) chromosome-positive CML. Resistance to interferon treatment and occurrence of blastic phase lead to the decision of imatinib therapy. After two autologous stem cell transplantation, the patient reverted to chronic phase...

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PMID: 12656747
DOI: 10.1034/j.1600-0609.2003.00046.x

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