Article
E355G mutation appearing in a patient with e19a2 chronic myeloid leukaemia resistant to imatinib.
Journal of clinical pathology - 1 Aug 2010
Bennour Ayda, Beaufils Nathalie, Sennana Halima, Meddeb Balkis, Saad Ali, Gabert Jean
Abstract excerpt
The development of imatinib is a milestone in the treatment of chronic myeloid leukaemia (CML), and its therapeutic effect has been extensively investigated in patients with CML who carry M-bcr and m-bcr BCR-ABL fusion transcripts. However, knowledge about its therapeutic effect on patients with CML who have the rare BCR-ABL fusion transcript e19a2 (mu-bcr) remains sparse. This report describes a patient with...
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