Article
Lysosomal high molecular weight multienzyme complex.
Cellular & molecular biology letters - 1 Jan 2003
Ostrowska Halina, Krukowska Katarzyna, Kalinowska Joanna, Orłowska Mirosława, Lengiewicz Ilona
Abstract excerpt
Three acidic glycosidases: beta-galactosidase (beta-GAL, EC 3.2.1.23), alpha-neuraminidase (NEUR, sialidase, EC 3.2.1.18), N-acetylaminogalacto-6-sulfate sulfatase (GALNS, EC 3.1.6.4) and serine carboxypepidase cathepsin A (EC 3.4.16.1) form a functional high molecular weight complex in the lysosomes. The major constituent of this complex is cathepsin A, the so-called "lysosomal protective protein" (PPCA). By...
Topics
- Cathepsin A
- Chondroitinsulfatases
- Humans
- Lysosomal Storage Diseases
- Lysosomes
- Molecular Weight
- Multienzyme Complexes
- Mutation
- Neuraminidase
- beta-Galactosidase