Dynamics of <i>Rickettsia</i> –tick interactions: identification and characterization of differentially expressed mRNAs in uninfected and infected <i>Dermacentor variabilis</i>

Abstract excerpt

To begin to explore the molecular dynamics of rickettsial tick interaction, subtractive hybridization was used to screen mRNAs in Rickettsia montanensis-infected and uninfected Dermacentor variabilis. We isolated 30 cDNA fragments, 22 of which were up-regulated and eight were down-regulated in response to rickettsial infection. Based on a putative identity of 11 cDNA fragments with similarity to known protein...

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