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Article

Immunological hurdles to lung gene therapy

24 Mar 2003

Abstract excerpt

Gene delivery has the potential to offer effective treatment to patients with life-threatening lung diseases such as cystic fibrosis, alpha1-antitrypsin deficiency and lung cancer. Phase I/II clinical trials have shown that, in principle, gene transfer to the lung is feasible and safe. However, gene expression from both viral and non-viral gene delivery systems has been inefficient. In addition to extra- and...

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PMID: 12653829
DOI: 10.1046/j.1365-2249.2003.02124.x

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