Article
Beneficial effects of fumarate therapy in psoriasis vulgaris patients coincide with downregulation of type 1 cytokines.
The British journal of dermatology - 1 Mar 2003
Litjens N H R, Nibbering P H, Barrois A J, Zomerdijk T P L, Van Den Oudenrijn A C, Noz K C, Rademaker M, Van De Meide P H, Van Dissel J T, Thio B
Abstract excerpt
BACKGROUND: Fumarates have been shown to be effective in psoriasis vulgaris. OBJECTIVES: To find out whether successful therapy is associated with modulation of cytokines. METHODS: We determined interferon (IFN)-gamma, interleukin (IL)-4 and IL-10 secretion capacities of peripheral blood mononuclear cells (PBMC) after phytohaemagglutinin stimulation, and IL-12p70 and IL-10 secretion capacities of PBMC after...
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