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A new human gene <i>KCNRG</i> encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3

11 Mar 2003

Abstract excerpt

We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3. This gene includes three exons and has two alternatively spliced isoforms that are expressed in normal tissues and in some tumor cell lines. Protein KCNRG has high homology to tetramerization domain of voltage-gated K+ channels. Using the patch-clamp technique we determined that KCNRG suppresses K+ channel activity in...

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PMID: 12650944
DOI: 10.1016/s0014-5793(03)00211-4

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