Article
Investigation of mitochondrial function in hereditary spastic paraparesis.
Neuroreport - 3 Mar 2003
McDermott C J, Taylor R W, Hayes C, Johnson M, Bushby K M D, Turnbull D M, Shaw P J
Abstract excerpt
Following the association of hereditary spastic paraparesis (HSP) with mutation in the paraplegin gene (SPG7) and mitochondrial dysfunction, we wished to investigate whether mitochondrial dysfunction might be associated with other forms of HSP. Five cases of HSP caused by mutation in the spastin gene (SPG4) and nine cases with HSP with mutation in the spastin and paraplegin genes excluded (non-SPG4/SPG7), were...
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