Article
The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients.
Journal of human genetics - 1 Jan 2003
Nomiyama Takashi, Tanaka Yasushi, Piao Lianshan, Nagasaka Keiko, Sakai Ken, Ogihara Takeshi, Nakajima Kunihiro, Watada Hirotaka, Kawamori Ryuzo
Abstract excerpt
We evaluated the relationship of an alanine or valine polymorphism at amino acid sequence 16 [Val(16)Ala] of manganese superoxide dismutase (Mn-SOD) with diabetes and diabetic nephropathy in Japanese type 2 diabetic patients. Val(16)Ala genotyping of Mn-SOD was done by polymerase chain reaction-restriction fragment length polymorphism with a restriction enzyme ( Bsaw I) in 478 Japanese type 2 diabetic patients...
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