Article
Integrated analysis of transcript profiling and protein sequence data.
Mechanisms of ageing and development - 1 Jan 2003
Grate L R, Bhattacharyya C, Jordan M I, Mian I S
Abstract excerpt
Transcript profiling can be used to elucidate the molecular and cellular mechanisms involved in ageing and cancer. A recent study of human gastrointestinal stromal tumours (GISTs) with mutations in the KIT gene, Cancer Res. 61 (2001) 8624 exemplifies a common type of investigation. cDNA microarrays were used to generate measurements for 1987 clones in two types of tissues: 13 KIT mutation-positive GISTs and 6...
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