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Article

Water molecule rearrangements around Leu93 and Trp182 in the formation of the L intermediate in bacteriorhodopsin's photocycle.

Biochemistry - 11 Mar 2003

Maeda Akio, Tomson Farol L, Gennis Robert B, Balashov Sergei P, Ebrey Thomas G

Abstract excerpt

After the chromophore's isomerization in the initial photochemical event in bacteriorhodopsin, the primary photoproduct K makes a thermal transition to the L intermediate, which prepares the pigment for Schiff base deprotonation in the following step (L --> M). Substantial changes in the hydrogen bonding of internal water molecules take place upon L formation. Some of these mobile waters are probably involved in...

Topics

Bacteriorhodopsins
Freezing
Hydrogen Bonding
Isomerism
Leucine
Methionine
Mutation
Phenylalanine
Photochemistry
Protein Conformation
Spectroscopy, Fourier Transform Infrared

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Temperature

Tryptophan

Water

Source

Identifiers

PMID: 12614147
DOI: 10.1021/bi020532n

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