Article
Pharmacogenetics and personalised medicine.
Fundamental & clinical pharmacology - 1 Oct 2002
Kalow Werner
Abstract excerpt
The traditional concern of pharmacogenetics was Mendelian (monogenic) variation, which visibly affected some drug responses. Pharmacogenetics was broadened by the observation that multifactorial genetic influences, in conjunction with environmental factors, usually determine drug responses. Variability of gene expression, a new theme of the science of genetics, also affects pharmacogenetics; for example, enhanced...
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