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Sex- and age-dependent human transcriptome variability: Implications for chronic heart failure

24 Feb 2003

Abstract excerpt

Heart failure (HF) is the end result of progressive and diverse biological adaptations within the diseased myocardium. We used cDNA microarrays and quantitative PCR to examine the transcriptomes of 38 left ventricles from failing and nonfailing human myocardium. After identification of a pool of putative HF-responsive candidate genes by microarrays on seven nonfailing and eight failing hearts, we used...

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PMID: 12601168
DOI: 10.1073/pnas.0436564100

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