Article
[Application of homozygosity mapping to the fine mapping of the osteoporosis-pseudoglioma syndrome locus].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Feb 2003
Gong Yao-qin, Li Jiang-xia, Liu Qi-ji, Chen Bing-xi, Guo Chen-hong, Gao Gui-min
Abstract excerpt
OBJECTIVE: To evaluate the role of homozygosity mapping in the fine mapping of the genes responsible for the rare autosomal recessive diseases. METHODS: Polymerase chain reaction-single sequence length polymorphism was used to genotype the family members from 8 families with osteoporosis-pseudoglioma syndrome(OPS) for 14 polymorphic loci within candidate region. The OPS candidate region was narrowed by searching...
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