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Article

PCR Assay for Identification of <i>Histoplasma capsulatum</i> Based on the Nucleotide Sequence of the M Antigen

1 Feb 2003

Abstract excerpt

The major diagnostic antigens of Histoplasma capsulatum var. capsulatum are the H and M antigens, pluripotent glycoproteins that elicit both humoral and T-cell-mediated immune responses. The gene encoding the M antigen has previously been sequenced, and its sequence has significant overall homology to those of the genes for fungal catalases. Regions of the M-antigen gene with little or no homology were used to...

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PMID: 12574242
DOI: 10.1128/jcm.41.2.535-539.2003

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