Article
Genetics of primary macronodular adrenal hyperplasia.
The Journal of endocrinology - 1 Jan 2015
Fragoso Maria Candida Barisson Villares, Alencar Guilherme Asmar, Lerario Antonio Marcondes, Bourdeau Isabelle, Almeida Madson Queiroz, Mendonca Berenice Bilharinho, Lacroix André
Abstract excerpt
ACTH-independent macronodular adrenal hyperplasia is a rare cause of Cushing's syndrome (CS), accounting for <2% of all endogenous CS cases; however it is more frequently identified incidentally with sub-clinical cortisol secretion. Recently, cortisol secretion has been shown to be regulated by ectopic corticotropin, which is in turn produced by clusters of steroidogenic cells of the hyperplastic adrenal nodules....
Topics
- Adenomatous Polyposis Coli
- Adrenal Cortex
- Adrenocorticotropic Hormone
- Animals
- Chromogranins
- Cushing Syndrome
- GTP-Binding Protein alpha Subunits, Gs
- Humans
- Multiple Endocrine Neoplasia Type 1
- Mutation
- Receptor, Melanocortin, Type 2