Article
Comprehensive scanning of the ATM gene with DOVAM-S.
Human mutation - 1 Feb 2003
Buzin Carolyn H, Gatti Richard A, Nguyen Vu Q, Wen Cindy Y, Mitui Midori, Sanal Ozden, Chen Jie Sheng, Nozari Guity, Mengos April, Li Xuemin, Fujimura Frank, Sommer Steve S
Abstract excerpt
Mutation detection at the ATM locus has been difficult because of the large size of the gene (66 exons), the fact that mutations are located throughout the entire gene with no hotspots, and the difficulty of distinguishing mutations from polymorphisms. In this study, the entire coding region (exons 4-65) was scanned, as well as the adjacent intronic regions, using DOVAM-S (Detection Of Virtually All...
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