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Expression and assembly of a fully active antibody in algae

8 Jan 2003

Abstract excerpt

Although combinatorial antibody libraries have solved the problem of access to large immunological repertoires, efficient production of these complex molecules remains a problem. Here we demonstrate the efficient expression of a unique large single-chain (lsc) antibody in the chloroplast of the unicellular, green alga, Chlamydomonas reinhardtii. We achieved high levels of protein accumulation by synthesizing the...

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PMID: 12522151
DOI: 10.1073/pnas.0237108100

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