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Article

A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology

4 Dec 2002

Abstract excerpt

We report a novel mutation of tau (L266V missense mutation in exon 9) which may cause a type of familial frontotemporal dementia. The brain of a patient showed Pick body-like inclusions and unique tau-positive, argyrophilic astrocytes with stout filaments and naked, round, or irregular argyrophilic inclusions with deposits of both three-repeat and four-repeat tau. Recombinant tau with a L266V mutation showed a...

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PMID: 12509859
DOI: 10.1002/ana.10447

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