Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Noisy clues to the origin of life.

Proceedings. Biological sciences - 7 Dec 2002

Krakauer David C, Sasaki Akira

Abstract excerpt

The origin of stable self-replicating molecules represents a fundamental obstacle to the origin of life. The low fidelity of primordial replicators places restrictions on the quantity of information encoded in a primitive nucleic acid alphabet. Further difficulties for the origin of life are the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Catalysis
Share to Genetic Drift

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Biological

Share to Mutation

Share to Nucleic Acids

Share to Proteins

Share to Stochastic Processes

Source

Open in PubMed Open full text

Identifiers

PMID: 12495484
DOI: 10.1098/rspb.2002.2127
PMCID: PMC1691173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12495484-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Noisy clues to the origin of life.PMID 12495484Read ↗

Lethal mutants and truncated selection together solve a paradox of the origin of life.Semantic proximity Read ↗

Evolutionary dynamics of RNA-like replicator systems: A bioinformatic approach to the origin of life.Semantic proximity Read ↗

Is life impossible? Information, sex, and the origin of complex organisms.Semantic proximity Read ↗

Life should be redefined: Any molecule with the ability to self-replicate should be considered lifeSemantic proximity Read ↗

Real ribozymes suggest a relaxed error threshold.Semantic proximity Read ↗

Recombination in primeval genomes: a step forward but still a long leap from maintaining a sizable genome.Semantic proximity Read ↗

Evolutionary model with Turing machines.Semantic proximity Read ↗

The evolutionary design of error-rates, and the fast fixation enigma.Semantic proximity Read ↗

Darwinian evolution in a translation-coupled RNA replication system within a cell-like compartment.Semantic proximity Read ↗

An engineer's view on genetic information and biological evolution.Semantic proximity Read ↗

LUCA as well as the ancestors of archaea, bacteria and eukaryotes were progenotes: Inference from the distribution and diversity of the reading mechanism of the AUA and AUG codons in the domains of life.Semantic proximity Read ↗

Local neutral networks help maintain inaccurately replicating ribozymes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.