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Article

Low-density lipoprotein receptor gene mutations and cardiovascular risk in a large genetic cascade screening population.

Circulation - 10 Dec 2002

Umans-Eckenhausen Marina A W, Sijbrands Eric J G, Kastelein John J P, Defesche Joep C

Abstract excerpt

BACKGROUND: A large cohort of patients with familial hypercholesterolemia (FH), free from selection for cardiovascular disease (CVD), and their unaffected relatives was collected by genetic cascade screening and examined for the influence of different mutations of the LDL receptor gene on lipoprotein levels and the risk of CVD. Multivariate analyses with adjustment for age, sex, and specific family ties were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12473547
DOI: 10.1161/01.cir.0000041253.61683.08

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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