Article
Akt signaling mediates VEGF/VPF vascular permeability in vivo.
FEBS letters - 4 Dec 2002
Six Isabelle, Kureishi Yasuko, Luo Zhengyu, Walsh Kenneth
Abstract excerpt
VEGF is an endothelial cell cytokine that promotes angiogenesis and enhances microvascular permeability. Recently, it has been shown that the protein kinase Akt functions in a key intercellular signaling pathway downstream of VEGF. Here, we employed adenovirus-mediated gene transfer in conjunction with the Miles assay in hairless albino guinea pigs to assess the role of Akt signaling in vascular permeability....
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