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BRCA1 and BRCA2 mutation analysis of early-onset and familial breast cancer cases in Mexico.

Human mutation - 1 Dec 2002

Ruiz-Flores Pablo, Sinilnikova Olga M, Badzioch Michael, Calderon-Garcidueñas A L, Chopin Sandrine, Fabrice Odefrey, González-Guerrero J F, Szabo Csilla, Lenoir Gilbert, Goldgar David E, Barrera-Saldaña Hugo A

Abstract excerpt

The entire coding regions of BRCA1 and BRCA2 were screened for mutations by heteroduplex analysis in 51 Mexican breast cancer patients. One BRCA1 and one BRCA2 truncating mutation each was identified in the group of 32 (6%) early-onset breast cancer patients (< or =35 years). Besides these two likely deleterious mutations, eight rare variants of unknown significance, mostly in the BRCA2 gene, were detected in six...

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Source

Identifiers

PMID: 12442275
DOI: 10.1002/humu.9084

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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