Article
Efficacy of lamivudine therapy for advanced liver disease in patients with precore mutant hepatitis B virus infection awaiting liver transplantation.
Transplantation - 27 Oct 2002
Andreone Pietro, Biselli Maurizio, Gramenzi Annagiulia, Cursaro Carmela, Morelli Maria C, Sama Claudia, Lorenzini Stefania, Spinucci Giulio, Porzio Federica, Felline Francesco, Di Giammarino Loriana, Bernardi Mauro
Abstract excerpt
BACKGROUND: Orthotopic liver transplantation (OLT) for end-stage liver disease resulting from hepatitis B virus (HBV) infection is associated with a high rate of recurrence and reduced survival. Lamivudine is effective in inhibiting HBV replication in patients with chronic hepatitis. This study evaluated the impact of lamivudine on viral suppression, liver function, and disease severity in patients awaiting OLT...
Topics
- Alanine Transaminase
- Cohort Studies
- Female
- Hepatitis B
- Hepatitis B virus
- Humans
- Lamivudine
- Liver Cirrhosis
- Liver Transplantation
- Male
- Middle Aged
- Mutation
- Preoperative Care