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Article

Genomic functional annotation using co-evolution profiles of gene clusters.

Genome biology - 10 Oct 2002

Zheng Yu, Roberts Richard J, Kasif Simon

Abstract excerpt

BACKGROUND: The current speed of sequencing already exceeds the capability of annotation, creating a potential bottleneck. A large proportion of the genes in microbial genomes remains uncharacterized. Here we propose a new method for functional annotation using the conservation patterns of gene clusters. If several gene clusters show the same coevolution pattern across different genomes it is reasonable to infer...

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Identifiers

PMID: 12429059
DOI: 10.1186/gb-2002-3-11-research0060
PMCID: PMC133444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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