Are Genital Infections and Inflammation Cofactors in the Pathogenesis of Invasive Cervical Cancer?

Abstract excerpt

It is well established that infection with high-risk types of human papillomavirus (HPV) is central to the pathogenesis of invasive cervical cancer. However, many women are infected with high-risk types of HPV, but only a subset of infected women will ever develop cervical cancer, suggesting that other cofactors must be present for the development of malignancy. Prior to the discovery of HPV, both Chlamydia and...

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