Article
Finding genetic contributions to sporadic disease: a recessive locus at 12q24 commonly contributes to patent ductus arteriosus.
Proceedings of the National Academy of Sciences of the United States of America - 12 Nov 2002
Mani Arya, Meraji Seyed-Mahmoud, Houshyar Roozbeh, Radhakrishnan Jayaram, Mani Alaleh, Ahangar Mehrabeh, Rezaie Tayebeh M, Taghavinejad Mohammad-Ali, Broumand Behrooz, Zhao Hongyu, Nelson-Williams Carol, Lifton Richard P
Abstract excerpt
The causes of many sporadic diseases are unexplained; the contribution of recessive loci with reduced penetrance is one possibility that has been difficult to explore. We describe an approach to this problem by first searching for diseases with higher prevalence in populations with high rates of consanguinity, then determining whether disease cases are more commonly the product of consanguinous union than...
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