The chemokine system: tuning and shaping by regulation of receptor expression and coupling in polarized responses

Abstract excerpt

Chemokines are a superfamily of small proteins with a crucial role in setup of immune and inflammatory reactions (1–4). At present, about 50 chemokines have been identified in humans. These molecules share a secondary structure with a flexible N-terminal segment followed by three antiparallel, β-sheets and a C-terminal α-helix, and according to the relative position of cysteine residues have been classified in...

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