Article
Genetics of pulmonary hypertension: from bench to bedside.
The European respiratory journal - 1 Sept 2002
Humbert M, Trembath R C
Abstract excerpt
Primary pulmonary hypertension has been described as either sporadic or clustered in families. Familial primary pulmonary hypertension segregates as an autosomal dominant trait with markedly reduced disease gene penetrance. Defects within bone morphogenetic protein receptor type II gene, coding for a receptor member of the transforming growth factor-beta family, underlie familial primary pulmonary hypertension....
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