Article
Growth hormone is required for ovarian follicular growth.
Endocrinology - 1 Oct 2002
Bachelot Anne, Monget Philippe, Imbert-Bolloré Prune, Coshigano Karen, Kopchick John J, Kelly Paul A, Binart Nadine
Abstract excerpt
To analyze the consequences of the absence of GH receptor (GHR) and GH-binding protein (GHBP) on female reproductive function, we used a mouse model in which the GHR/GHBP gene has been disrupted by homologous recombination. The major effect on reproductive function seen in GHR/GHBP knockout (KO) compared with wild-type animals is a dramatic decrease in litter size; this defect is due to a reduction of the...
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