Article
PrfA protein of Bacillus species: prediction and demonstration of endonuclease activity on DNA.
Protein science : a publication of the Protein Society - 1 Oct 2002
Rigden Daniel J, Setlow Peter, Setlow Barbara, Bagyan Irina, Stein Richard A, Jedrzejas Mark J
Abstract excerpt
The prfA gene product of Gram-positive bacteria is unusual in being implicated in several cellular processes; cell wall synthesis, chromosome segregation, and DNA recombination and repair. However, no homology of PrfA with other proteins has been evident. Here we report a structural relationship between PrfA and the restriction enzyme PvuII, and thereby produce models that predict that PrfA binds DNA. Indeed,...
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