Discrete Proteolysis of Focal Contact and Adherens Junction Components in <i>Porphyromonas gingivalis-</i> Infected Oral Keratinocytes: a Strategy for Cell Adhesion and Migration Disabling

Abstract excerpt

Adhesive interactions of cells are critical to tissue integrity. We show that infection with Porphyromonas gingivalis, a major pathogen in the periodontal disease periodontitis, interferes with both cell-matrix and cell-cell adhesion in the oral keratinocyte cell line HOK-16. Thus, infected cells showed reduced adhesion to extracellular matrix, changes in morphology from spread to rounded, and impaired motility...

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