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Article

Complete replacement of basic amino acid residues with cysteines in Rickettsia prowazekii ATP/ADP translocase.

Biochimica et biophysica acta - 20 Sept 2002

Alexeyev Mikhail F, Winkler Herbert H

Abstract excerpt

The ATP/ADP translocase (Tlc) of Rickettsia prowazekii is a basic protein with isoelectric point (pI)=9.84. It is conceivable, therefore, that basic residues in this protein are involved in electrostatic interactions with negatively charged substrates. We tested this hypothesis by individually mutating all basic residues in Tlc to Cys. Unexpectedly, mutations of only 20 out of 51 basic residues resulted in...

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Identifiers

PMID: 12225862
DOI: 10.1016/s0005-2736(02)00544-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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