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Article

Autocrine motility factor secreted by tumor cells upregulates vascular endothelial growth factor receptor (Flt-1) expression in endothelial cells.

International journal of cancer - 20 Sept 2002

Funasaka Tatsuyoshi, Haga Arayo, Raz Avraham, Nagase Hisamitsu

Abstract excerpt

The autocrine motility factor (AMF) is known as a cytokine regulating tumor cells motility via AMF receptor (AMFR) and promotes their metastasis. Recently, AMFRs have been found on the surface of host cells and it was showed that AMF possibly affects them. The signaling of AMF-AMFR in the host endothelial cells induces expression of a vascular endothelial growth factor receptor (VEGFR) Flt-1 and AMFR feedback...

Read the complete abstract on PubMed

Topics

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Share to Endothelium, Vascular
Share to Glucose-6-Phosphate Isomerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to Neovascularization, Physiologic

Share to Protein Kinase C

Share to Receptor Protein-Tyrosine Kinases

Share to Receptors, Cytokine

Share to Vascular Endothelial Growth Factor Receptor-1

Source

Identifiers

PMID: 12209971
DOI: 10.1002/ijc.10617

Genes

AMFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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